Consanguinity and susceptibility to infectious diseases in humans
نویسندگان
چکیده
منابع مشابه
Consanguinity and susceptibility to infectious diseases in humans
Studies of animal populations suggest that low genetic heterozygosity is an important risk factor for infection by a diverse range of pathogens, but relatively little research has looked to see whether similar patterns exist in humans. We have used microsatellite genome screen data for tuberculosis (TB), hepatitis and leprosy to test the hypothesis that inbreeding depression increases risk of i...
متن کاملCISH and susceptibility to infectious diseases.
BACKGROUND The interleukin-2-mediated immune response is critical for host defense against infectious pathogens. Cytokine-inducible SRC homology 2 (SH2) domain protein (CISH), a suppressor of cytokine signaling, controls interleukin-2 signaling. METHODS Using a case-control design, we tested for an association between CISH polymorphisms and susceptibility to major infectious diseases (bactere...
متن کاملPregnancy and Susceptibility to Infectious Diseases
To summarize the literature regarding susceptibility of pregnant women to infectious diseases and severity of resulting disease, we conducted a review using a PubMed search and other strategies. Studies were included if they reported information on infection risk or disease outcome in pregnant women. In all, 1454 abstracts were reviewed, and a total of 85 studies were included. Data were extrac...
متن کاملEvolutionary Determinants of Genetic Variation in Susceptibility to Infectious Diseases in Humans
Although genetic variation among humans in their susceptibility to infectious diseases has long been appreciated, little focus has been devoted to identifying patterns in levels of variation in susceptibility to different diseases. Levels of genetic variation in susceptibility associated with 40 human infectious diseases were assessed by a survey of studies on both pedigree-based quantitative v...
متن کاملGenetics of Susceptibility to Infectious Diseases
W e and microbial pathogens are often locked inadynamicbattlemediated by their virulence factors and our defenses. If we do not mount effective immune responses to pathogens, we will not overcome infections. However, if we overreact, host immune cascades may make those infections more severe. Both nonspecific factors, such as age and general health status, as well as specific genetic factors co...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biology Letters
سال: 2009
ISSN: 1744-9561,1744-957X
DOI: 10.1098/rsbl.2009.0133